Ncoa3 | nuclear receptor coactivator 3

GeneMGI:1276535Synonyms: TRAM-1, pCIP, +7 more

Physiological systems

19 / 24 physiological systems tested

7 Significantly impacted by the knock-out

Homeostasis/metabolism Growth/size/body region Vision/eye Hematopoietic system Skeleton Craniofacial Mortality/aging

12 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:7Significant phenotypes

0Associated diseases

Expression examined in:46Adult tissues

42Embryo tissues

Phenotypes

Zygosity:

Phy. System:



preweaning lethality, incomplete penetrance	1 supporting dataset	Ncoa3^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
persistence of hyaloid vascular system	1 supporting dataset	Ncoa3^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	4.84x10^-7
increased mean corpuscular hemoglobin	1 supporting dataset	Ncoa3^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	9.73x10^-5
thrombocytopenia	1 supporting dataset	Ncoa3^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	5.06x10^-6
persistence of hyaloid vascular system	1 supporting dataset	Ncoa3^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	1.49x10^-7
abnormal tooth morphology	1 supporting dataset	Ncoa3^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	6.94x10^-14
increased circulating bilirubin level	1 supporting dataset	Ncoa3^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	7.1x10^-8
impaired glucose tolerance	1 supporting dataset	Ncoa3^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	9.47x10^-9
abnormal tooth morphology	1 supporting dataset	Ncoa3^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	2.73x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Ncoa3.

Associated images

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Histopathology

There is no histopathology data found for Ncoa3.

IMPC related publications

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External links

No external links available for Ncoa3.

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*Ncoa3^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	es cell
*Ncoa3^{tm1(NCOM)Mfgc}*	Reporter-tagged deletion allele (with selection cassette)	‌	targeting vector es cell
*Ncoa3^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Ncoa3^{tm1b(EUCOMM)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse

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