Ncoa3 | nuclear receptor coactivator 3
Physiological systems
19 / 24 physiological systems tested
7 Significantly impacted by the knock-out
Homeostasis/metabolism Growth/size/body region Vision/eye Hematopoietic system Skeleton Craniofacial Mortality/aging
12 No significant impact
5 Not tested
Gene metrics:7Significant phenotypes
0Associated diseases
Expression examined in:46Adult tissues
42Embryo tissues
| preweaning lethality, incomplete penetrance | 1 supporting dataset | Ncoa3tm1b(EUCOMM)Wtsi | homozygote | Early adult | N/A * | ||
| persistence of hyaloid vascular system | 1 supporting dataset | Ncoa3tm1b(EUCOMM)Wtsi | heterozygote | Early adult | 4.84x10-7 | ||
| increased mean corpuscular hemoglobin | 1 supporting dataset | Ncoa3tm1b(EUCOMM)Wtsi | heterozygote | Early adult | 9.73x10-5 | ||
| thrombocytopenia | 1 supporting dataset | Ncoa3tm1b(EUCOMM)Wtsi | heterozygote | Early adult | 5.06x10-6 | ||
| persistence of hyaloid vascular system | 1 supporting dataset | Ncoa3tm1b(EUCOMM)Wtsi | homozygote | Early adult | 1.49x10-7 | ||
| abnormal tooth morphology | 1 supporting dataset | Ncoa3tm1b(EUCOMM)Wtsi | heterozygote | Early adult | 6.94x10-14 | ||
| increased circulating bilirubin level | 1 supporting dataset | Ncoa3tm1b(EUCOMM)Wtsi | heterozygote | Early adult | 7.1x10-8 | ||
| impaired glucose tolerance | 1 supporting dataset | Ncoa3tm1b(EUCOMM)Wtsi | heterozygote | Early adult | 9.47x10-9 | ||
| abnormal tooth morphology | 1 supporting dataset | Ncoa3tm1b(EUCOMM)Wtsi | homozygote | Early adult | 2.73x10-5 |
| | | | | | | | | | |
| adrenal gland | heterozygote | n/a | 0% (0/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 100% (2/2) | 0.19% (1/533) |
| bone | heterozygote | n/a | 0% (0/2) | 0% (0/394) |
| brain | heterozygote | n/a | 0% (0/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | 0% (0/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 0% (0/2) | 0.22% (1/454) |
| cerebellum | heterozygote | n/a | 0% (0/2) | 0.56% (3/532) |
| cerebral cortex | heterozygote | n/a | 0% (0/2) | 0.41% (2/491) |
| esophagus | heterozygote | n/a | 100% (2/2) | 1.67% (7/419) |
Human diseases caused by Ncoa3 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Ncoa3.
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| Ncoa3tm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | ES Cell |
| Ncoa3tm1(NCOM)Mfgc | Reporter-tagged deletion allele (with selection cassette) | | targeting vector ES Cell |
| Ncoa3tm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Ncoa3tm1b(EUCOMM)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |